The effect of live, attenuated measles vaccine and measles infection on measles antibody levels in serum and CSF of patients with multiple sclerosis or clinically isolated syndrome

J Neuroimmunol. 2011 Jun;235(1-2):98-103. doi: 10.1016/j.jneuroim.2011.04.002. Epub 2011 May 7.


High occurrence of measles, rubella and varicella zoster antibodies has been used as a biomarker for MS (the MRZ test). We analyzed measles antibody titres with respect to measles infection/measles vaccination status in 166 patients with MS or clinically isolated syndrome. Fifty blood donors served as controls. Measles vaccination yielded CSF measles antibodies in fewer patients (62%) than measles infection did (87%, p=0.001) and yielded lower measles titres in both serum and CSF (p<0.001). Controls had lower CSF measles titres than patients with measles vaccination alone (p<0.001). Childhood vaccinations probably reduce the sensitivity of the MRZ diagnostic test for MS.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Viral / blood*
  • Antibodies, Viral / cerebrospinal fluid*
  • Child, Preschool
  • Demyelinating Diseases / blood
  • Demyelinating Diseases / cerebrospinal fluid
  • Demyelinating Diseases / immunology*
  • Female
  • Humans
  • Male
  • Measles / blood
  • Measles / cerebrospinal fluid
  • Measles / immunology*
  • Measles Vaccine / immunology*
  • Measles Vaccine / therapeutic use
  • Middle Aged
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / immunology*
  • Vaccines, Attenuated / immunology
  • Vaccines, Attenuated / therapeutic use
  • Young Adult


  • Antibodies, Viral
  • Measles Vaccine
  • Vaccines, Attenuated