A chemoenzymatic synthesis of 5a-carba-α-D-mannose-6-phosphate

Paula M Williams; Gary N Sheldrake; Simon J F Macdonald; Chris J Hamilton

doi:10.1016/j.carres.2011.04.011

A chemoenzymatic synthesis of 5a-carba-α-D-mannose-6-phosphate

Carbohydr Res. 2011 Jul 15;346(10):1257-61. doi: 10.1016/j.carres.2011.04.011. Epub 2011 Apr 12.

Authors

Paula M Williams¹, Gary N Sheldrake, Simon J F Macdonald, Chris J Hamilton

Affiliation

¹ School of Chemistry and Chemical Engineering, David Kerr Building, Queen's University Belfast, Stranmillis Rd, Belfast BT9 5DG, United Kingdom.

PMID: 21550596
DOI: 10.1016/j.carres.2011.04.011

Abstract

An efficient chemical synthesis of 5a-carba-α-D-mannose and its enzymatic elaboration to 5a-carba-α-D-mannose-6-phosphate, using yeast hexokinase, is described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hexokinase / chemistry*
Mannosephosphates / chemical synthesis*
Mannosephosphates / chemistry
Models, Chemical
Saccharomyces cerevisiae / enzymology*
Trisaccharides / chemical synthesis*
Trisaccharides / chemistry

Substances

Mannosephosphates
Trisaccharides
5a-carba-2-O-mannopyranosylmannopyranose
mannose-6-phosphate
Hexokinase