The interaction between bovine herpesvirus type 1 and activated bovine T lymphocytes

J Gen Virol. 1990 Feb;71 ( Pt 2):369-77. doi: 10.1099/0022-1317-71-2-369.

Abstract

The interaction between activated bovine T lymphocytes (BTLs) and bovine herpesvirus type 1 (BHV-1) was investigated. BHV-1 infection of BTLs reduced the amplitude of recombinant bovine interleukin 2-induced proliferative responses. This decreased proliferation was caused by a virus-induced lymphocytolysis which was dependent on viable virus and was not inhibited by recombinant bovine interferon-alpha I1. Furthermore, lymphocytolysis was not associated with virus replication or with the synthesis of detectable levels of viral proteins. Electron microscopic examination of virus-infected cells revealed that lymphocytolysis was characterized by early nuclear disintegration resembling apoptosis. These observations suggest that activated T cells, localized at the site of BHV-1 infection, may be susceptible to virus-induced cytolysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoradiography
  • Cattle
  • Cell Survival
  • Cells, Cultured
  • Electrophoresis, Polyacrylamide Gel
  • Herpesvirus 1, Bovine / physiology*
  • Interleukin-2 / pharmacology
  • Lymphocyte Activation
  • T-Lymphocytes / immunology
  • T-Lymphocytes / microbiology*
  • Viral Proteins / analysis
  • Virus Replication

Substances

  • Interleukin-2
  • Viral Proteins