Emergency department visits for antiviral adverse events during the 2009 H1N1 influenza pandemic

Public Health Rep. May-Jun 2011;126(3):312-7. doi: 10.1177/003335491112600303.


The 2009 pandemic influenza A (H1N1) outbreak was associated with an increased use of antiviral agents and highlighted the role of population-based monitoring for related adverse drug events (ADEs). An ongoing, nationally representative emergency department-based surveillance system was used to identify and characterize ADEs during the pandemic. Active surveillance for ADEs successfully provided timely, population-based data during the pandemic. Increases in antiviral ADEs paralleled increases in prescribing. Type and severity of ADEs were similar across all seasons.

MeSH terms

  • Adolescent
  • Adult
  • Adverse Drug Reaction Reporting Systems*
  • Aged
  • Antiviral Agents / adverse effects*
  • Child
  • Disease Outbreaks
  • Drug-Related Side Effects and Adverse Reactions / epidemiology*
  • Emergency Service, Hospital / statistics & numerical data*
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype*
  • Influenza, Human / drug therapy*
  • Influenza, Human / virology
  • Male
  • Middle Aged
  • Outpatients
  • Population Surveillance
  • United States / epidemiology


  • Antiviral Agents