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. 2011 May-Jun;126(3):354-60.
doi: 10.1177/003335491112600309.

Trends in hospitalizations with antibiotic-resistant infections: U.S., 1997-2006

Arch G Mainous 3rd  1 , Vanessa A Diaz, Eric M Matheson, Seth H Gregorie, William J Hueston
Affiliations

Trends in hospitalizations with antibiotic-resistant infections: U.S., 1997-2006

Arch G Mainous 3rd et al. Public Health Rep. 2011 May-Jun.

Abstract

Objectives: Antibiotic resistance is a significant global problem, but the trends in prevalence and impact of antibiotic resistance in hospitalizations in the United States are unclear. We evaluated the trends in hospitalizations associated with antibiotic-resistant infections in U.S. hospitals from 1997 to 2006.

Methods: We analyzed the National Hospital Discharge Survey (NHDS) during 1997-2006 (unweighted n = 3.3 million hospitalizations; weighted n = 370.3 million hospitalizations) and examined trends in prevalence of hospitalizations with antibiotic-resistant infections, length of stay, and discharge status.

Results: The number of infection-related hospitalizations with antibiotic resistance increased 359% during the 10-year period, from 37,005 in 1997 to 169,985 in 2006. The steepest rise was seen among individuals < 18 years of age. The mean age of individuals with infection-related hospitalizations that had antibiotic-resistant infections decreased substantially, from 65.7 years (standard error [SE] = 2.01) in 1997 to 44.2 years (SE = 1.47) in 2006. As the proportion of patients with antibiotic-resistant infections who did not have insurance increased, the length of stay for those hospitalizations had a corresponding decrease (r = 0.91, p < 0.01).

Conclusions: Antibiotic-resistant infections are becoming increasingly commonplace in hospitalizations in the U.S., with a steady upward trend between 1997 and 2006. Antibiotic-resistant infections are increasingly being seen in younger patients and those without health insurance.

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Figures

Figure 1.
Figure 1.
Percentage of infection-related hospitalizations with antibiotic-resistant microorganisms, grouped by age: U.S., 1997–2006
Figure 2.
Figure 2.
Median length of stay in hospital and percent insured, with and without antibiotic resistance: U.S., 1997–2006
Figure 3.
Figure 3.
Discharge status of hospitalizations with antibiotic-resistant infections: U.S., 1997–2006
See this image and copyright information in PMC

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