Endocrine assessment of prepubertal boys with a history of cryptorchidism and/or hypospadias: a pilot study

J Urol. 2011 Jun;185(6 Suppl):2444-50. doi: 10.1016/j.juro.2011.01.018. Epub 2011 Apr 28.


Purpose: Four disorders, including poor semen quality, testicular cancer, cryptorchidism and hypospadias, are thought to represent testicular dysgenesis syndrome and have been hypothesized to share a common etiology. We predicted testicular function in prepubertal boys with a history of cryptorchidism and/or hypospadias by measuring serum hormone levels.

Materials and methods: A total of 82 prepubertal boys who underwent orchiopexy and/or hypospadias repair in childhood were enrolled in the study. Patients were surgically treated for cryptorchidism (23 in group 1), hypospadias (49 in group 2), cryptorchidism and hypospadias (10 in group 3), and hydrocele testis (7 in control group 4). Serum hormones, including luteinizing hormone, follicle-stimulating hormone and total testosterone, were measured separately by age less than 12.5, 12.5 to 13.5 and greater than 13.5 years, and by Tanner pubertal stage.

Results: Follicle-stimulating hormone in group 3 was significantly higher than in groups 1, 2 and 4 at ages 12.5 to 13.5 and greater than 13.5 years, and for Tanner stages 2 and 3 (p <0.05). However, luteinizing hormone and testosterone did not differ among the groups regardless of age or Tanner stage. Group 3 patients had significantly higher follicle-stimulating hormone regardless of the severity of cryptorchidism or hypospadias.

Conclusions: Data suggest that testicular function in patients with cryptorchidism plus hypospadias is more severely impaired than that in patients with cryptorchidism or hypospadias, lending clinical support to the testicular dysgenesis syndrome hypothesis of a common origin.

MeSH terms

  • Adolescent
  • Child
  • Cryptorchidism / blood*
  • Cryptorchidism / complications
  • Follicle Stimulating Hormone / blood*
  • Humans
  • Hypospadias / blood*
  • Hypospadias / complications
  • Luteinizing Hormone / blood*
  • Male
  • Pilot Projects
  • Retrospective Studies
  • Testosterone / blood*


  • Testosterone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone