Recommendations of the European Association of Echocardiography: how to use echo-Doppler in clinical trials: different modalities for different purposes

Eur J Echocardiogr. 2011 May;12(5):339-53. doi: 10.1093/ejechocard/jer051.


The European Association of Echocardiography (EAE) has developed the present recommendations to assist clinical researchers in the design, implementation, and conduction of echocardiographic protocols for clinical trials and to guarantee their quality. Clinical trials should be designed and conducted based on the knowledge of the pathophysiology of the clinical condition studied, the technical characteristics of the echo-Doppler modalities, and the variability of the tested parameters. These procedures are important to choose the most reliable and reproducible techniques and parameters. Quality assurance must be guaranteed by adequate training of peripheral site operators to obtain optimal echo-Doppler data and by using a core laboratory for accurate and reproducible data analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Clinical Trials as Topic / standards*
  • Echocardiography, Doppler / instrumentation
  • Echocardiography, Doppler / methods*
  • Echocardiography, Doppler / standards
  • Europe
  • Health Status Indicators
  • Heart Diseases / diagnostic imaging*
  • Heart Diseases / pathology
  • Heart Valve Diseases / diagnostic imaging
  • Heart Valve Diseases / pathology
  • Heart Ventricles / diagnostic imaging
  • Heart Ventricles / pathology
  • Humans
  • Hypertrophy, Left Ventricular / diagnostic imaging
  • Hypertrophy, Left Ventricular / pathology
  • Prognosis
  • Quality of Health Care / standards*
  • Societies, Medical*
  • Statistics as Topic
  • Stroke Volume
  • Systole
  • Ventricular Function, Right