Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study

Arch Neurol. 2011 May;68(5):656-9. doi: 10.1001/archneurol.2011.93.


Objective: To investigate the distribution of lobar microbleeds over the different lobes, taking into account lobar volume and clustering effects of multiple microbleeds.

Design: Population-based, cross-sectional analysis.

Setting: The Rotterdam Scan Study.

Participants: A total of 198 persons (age range, 61-95 years) with lobar microbleeds.

Main outcome measures: Distribution of microbleeds over different lobes.

Results: We found that lobar cerebral microbleeds occurred significantly more often in the temporal lobe, a region known to be more affected in cerebral amyloid angiopathy.

Conclusion: This study corroborates the presumed association of lobar microbleeds with cerebral amyloid angiopathy.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cerebral Amyloid Angiopathy / complications*
  • Cerebral Amyloid Angiopathy / diagnosis*
  • Cerebral Amyloid Angiopathy / epidemiology
  • Cerebral Cortex / blood supply*
  • Cerebral Hemorrhage / complications*
  • Cerebral Hemorrhage / diagnosis*
  • Cerebral Hemorrhage / epidemiology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Microcirculation
  • Middle Aged
  • Netherlands / epidemiology
  • Organ Size
  • Temporal Lobe / blood supply