A spatially extended model for macroscopic spike-wave discharges

J Comput Neurosci. 2011 Nov;31(3):679-84. doi: 10.1007/s10827-011-0332-1. Epub 2011 May 10.

Abstract

Spike-wave discharges are a distinctive feature of epileptic seizures. So far, they have not been reported in spatially extended neural field models. We study a space-independent version of the Amari neural field model with two competing inhibitory populations. We show that this competition leads to robust spike-wave dynamics if the inhibitory populations operate on different time-scales. The spike-wave oscillations present a fold/homoclinic type bursting. From this result we predict parameters of the extended Amari system where spike-wave oscillations produce a spatially homogeneous pattern. We propose this mechanism as a prototype of macroscopic epileptic spike-wave discharges. To our knowledge this is the first example of robust spike-wave patterns in a spatially extended neural field model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / physiology*
  • Biological Clocks / physiology
  • Cerebral Cortex / physiopathology*
  • Cortical Synchronization / physiology
  • Epilepsy / physiopathology*
  • Humans
  • Interneurons / physiology*
  • Models, Neurological*
  • Nerve Net / physiology