Peritoneal immune system in patients with advance epithelial ovarian cancer

Int Rev Immunol. 2011 Apr-Jun;30(2-3):87-101. doi: 10.3109/08830185.2011.569902.


The development of epithelial ovarian cancer is associated with changes in the peritoneal cavity microenvironment. Tumor cells produce different factors, which impairs differentiation, maturation, and function of antigen-presenting cells. In this review, we focus on selected cell populations in the peritoneal cavity immune system and their potential role in epithelial ovarian cancer immunopathogenesis. We devote most attention to dendritic cells because they are considered to be superior in their antigen-presenting ability, compared with both macrophages and B lymphocytes. We also present a brief characterization of tumor-infiltraiting cells in epithelial ovarian cancer patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Ascitic Fluid / cytology*
  • Ascitic Fluid / immunology*
  • Carcinoma, Ovarian Epithelial
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Female
  • Humans
  • Immune System / immunology
  • Lymphocytes, Tumor-Infiltrating / cytology
  • Lymphocytes, Tumor-Infiltrating / immunology*
  • Neoplasms, Glandular and Epithelial / immunology
  • Neoplasms, Glandular and Epithelial / pathology
  • Ovarian Neoplasms / immunology
  • Ovarian Neoplasms / pathology