Randomized controlled trial on lateral augmentation using two collagen membranes: morphometric results on mineralized tissue compound

J Clin Periodontol. 2011 Jul;38(7):677-85. doi: 10.1111/j.1600-051X.2011.01738.x. Epub 2011 May 10.


Background: Guided bone regeneration is considered an effective tool for gaining mineralized tissue either at exposed implant surface or in deficient alveolar ridge areas before implant placement.

Material and methods: Customized casts obtained following impression taking at surgery and re-entry allowed for morphometric assessment of alveolar ridge alterations 6 months after one-stage augmentation of bone dehiscences. In a randomized pilot study using biphasic calcium phosphate tests (n=17) received treatment with ribose cross-linked collagen membranes (RCLM), whereas controls (n=20) received non-cross-linked membranes. The primary endpoint was to quantify the effect of membrane type on dimensional changes in bone margins at crestal level of endosseous implants.

Results: Soft tissue dehiscencies occurred at 70.5% and 55% frequency for tests and controls, respectively. Gain in clinically hard newly mineralized tissue at the crestal level was significantly higher in test group in lateral (1.8 versus 0.7 mm; p=.046) and in vertical dimensions (1.1 versus 0.2 mm; p=.035) compared with controls. Second measurement obtained at the border of reflected flap revealed no significant difference between groups (3.0 versus 2.1 mm; p=0.57) for lateral dimension.

Conclusions: Both collagen devices were effective in bone augmentation. RCLMs supported mineralization process and remodelling even in sites showing compromised healing as indicated by morphometric outcome.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alveolar Process / pathology
  • Alveolar Ridge Augmentation / methods*
  • Biocompatible Materials / chemistry
  • Bone Remodeling / physiology
  • Bone Substitutes / therapeutic use*
  • Calcification, Physiologic / physiology
  • Cephalometry
  • Collagen* / chemistry
  • Cross-Linking Reagents / chemistry
  • Dental Implantation, Endosseous / methods
  • Dental Implants
  • Female
  • Follow-Up Studies
  • Humans
  • Hydroxyapatites / therapeutic use
  • Jaw, Edentulous, Partially / rehabilitation
  • Jaw, Edentulous, Partially / surgery
  • Male
  • Membranes, Artificial*
  • Middle Aged
  • Pilot Projects
  • Ribose / chemistry
  • Single-Blind Method
  • Surgical Wound Dehiscence / etiology
  • Treatment Outcome
  • Young Adult


  • Bio-Gide
  • Biocompatible Materials
  • Bone Substitutes
  • BoneCeramic
  • Cross-Linking Reagents
  • Dental Implants
  • Hydroxyapatites
  • Membranes, Artificial
  • Ossix
  • Ribose
  • Collagen