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Randomized Controlled Trial
. 2011 Aug;65(8):972-7.
doi: 10.1038/ejcn.2011.59. Epub 2011 May 11.

Broccoli Sprouts Reduce Oxidative Stress in Type 2 Diabetes: A Randomized Double-Blind Clinical Trial

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Randomized Controlled Trial

Broccoli Sprouts Reduce Oxidative Stress in Type 2 Diabetes: A Randomized Double-Blind Clinical Trial

Z Bahadoran et al. Eur J Clin Nutr. .

Abstract

Background/objectives: In vitro and animal studies have reported that young broccoli sprouts improve oxidative stress status in diabetic condition. The objective of this double-blind, placebo-controlled, randomized clinical trial was to investigate the effects of broccoli sprouts powder (BSP) on some oxidative stress parameters in type 2 diabetes patients.

Subjects/methods: A total of 81 patients with type 2 diabetes were randomly assigned to one of three treatment groups for 4 weeks. The groups received either 10 g/d BSP (n=27), 5 g/d BSP (n=29) or placebo (n=25). Serum total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and oxidized low density lipoprotein (LDL) cholesterol were measured at baseline and at 4 weeks after treatment.

Results: In all, 63 patients in three groups were included in the analysis: 10 g/d BSP (n=21), 5 g/d (n=22) and placebo (n=20). After 4 weeks, consumption of BSP resulted in significant decrease in MDA (P=0.001 for treatment effect), oxidized low density lipoprotein cholesterol (P=0.03 for treatment effect), OSI (P=0.001 for treatment effect) and significant increase in TAC (P=0.001 for treatment effect). No effects were found on TOS.

Conclusion: BSP had favorable effects on oxidative stress status in type 2 diabetes patients.

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