Higher adherence to French dietary guidelines and chronic diseases in the prospective SU.VI.MAX cohort

Eur J Clin Nutr. 2011 Aug;65(8):887-94. doi: 10.1038/ejcn.2011.61. Epub 2011 May 11.


Background/objectives: Nutritional recommendations are widely disseminated, but assessment of their predictive value for risk of chronic diseases and mortality is essential for ensuring their validity. We evaluated, in a large population-based study, the association between the French Programme National Nutrition Santé (PNNS) Guideline Score (GS) (maximum score of 15 points), an a priori-based score, and the incidences of cancer, cardiovascular disease (CVD) and overall mortality.

Subjects/methods: Subjects included in this analysis (n=5823) were participants in the Supplémentation en Vitamines et Minéraux AntioXydants study, with available data for estimating the PNNS-GS. Hazards ratios (HRs) and 95% confidence intervals (95% CIs) for outcomes (cancer, CVD and death) were estimated across quartiles of PNNS-GS using Cox proportional hazards models.

Results: A total of 734 major events were recorded during an average 11.6-year follow-up (maximum 13 years): 423 cancers, 193 ischemic diseases and 118 deaths. In the fully adjusted model, a significant reduction in CVD risk between the first and fourth PNNS-GS quartiles (HR=0.65, 95% CI=0.41, 1.00, P for trend=0.04) was observed. No significant overall association with risk of cancer or death was detected.

Conclusions: These observations support the role of nutritional guidelines in prevention of CVD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / prevention & control
  • Chronic Disease
  • Diet / standards*
  • Double-Blind Method
  • Feeding Behavior*
  • Female
  • Follow-Up Studies
  • Guidelines as Topic
  • Humans
  • Life Style
  • Male
  • Middle Aged
  • Patient Compliance*
  • Predictive Value of Tests
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Surveys and Questionnaires