Long-term in-vitro precision of direct digital X-ray radiogrammetry

Skeletal Radiol. 2011 Dec;40(12):1575-9. doi: 10.1007/s00256-011-1187-2. Epub 2011 May 11.


Objective: Digital X-ray radiogrammetry (DXR) calculates peripheral bone mineral density (BMD) from hand radiographs. The short-term precision for direct DXR has been reported to be highly satisfactory. However, long-term precision for this method has not been examined. Thus, the aim of this study was to examine the long-term in-vitro precision for the new direct digital version of DXR.

Materials and methods: The in-vitro precision for direct DXR was tested with cadaver phantoms on four different X-ray systems at baseline, 3 months, 6 months, and in one machine also at 12 months. At each time point, 31 measurements were performed.

Results: The in-vitro longitudinal precision for the four radiographic systems ranged from 0.22 to 0.43% expressed as coefficient of variation (CV%). The smallest detectable difference (SDD) ranged from 0.0034 to 0.0054 g/cm(2).

Conclusions: The in vitro long-term precision for direct DXR was comparable to the previous reported short-term in-vitro precision for all tested X-ray systems. These data show that DXR is a stable method for detecting small changes in bone density during 6-12 months of follow-up.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bone Density*
  • Cadaver
  • Hand / diagnostic imaging*
  • Humans
  • Phantoms, Imaging
  • Radiographic Image Enhancement*
  • Reproducibility of Results
  • Time Factors