Paneth cell α-defensins in enteric innate immunity

Cell Mol Life Sci. 2011 Jul;68(13):2215-29. doi: 10.1007/s00018-011-0714-6. Epub 2011 May 11.


Paneth cells at the base of small intestinal crypts of Lieberkühn secrete high levels of α-defensins in response to cholinergic and microbial stimuli. Paneth cell α-defensins are broad spectrum microbicides that function in the extracellular environment of the intestinal lumen, and they are responsible for the majority of secreted bactericidal peptide activity. Paneth cell α-defensins confer immunity to oral infection by Salmonella enterica serovar Typhimurium, and they are major determinants of the composition of the small intestinal microbiome. In addition to host defense molecules such as α-defensins, lysozyme, and Pla2g2a, Paneth cells also produce and release proinflammatory mediators as components of secretory granules. Disruption of Paneth cell homeostasis, with subsequent induction of endoplasmic reticulum stress, autophagy, or apoptosis, contributes to inflammation in diverse genetic and experimental mouse models.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Gene Expression
  • Host-Pathogen Interactions
  • Metagenome / immunology
  • Mice
  • Molecular Sequence Data
  • Paneth Cells / immunology*
  • Paneth Cells / microbiology
  • Protein Conformation
  • Salmonella Infections / immunology
  • Salmonella typhimurium / immunology
  • Secretory Vesicles / immunology
  • alpha-Defensins / chemistry
  • alpha-Defensins / genetics
  • alpha-Defensins / metabolism*


  • alpha-Defensins