Oral administration of marine collagen peptides from Chum Salmon skin enhances cutaneous wound healing and angiogenesis in rats

J Sci Food Agric. 2011 Sep;91(12):2173-9. doi: 10.1002/jsfa.4435. Epub 2011 May 10.


Background: A wound is a clinical entity which often poses problems in clinical practice. The present study was aimed to investigate the wound healing potential of administering marine collagen peptides (MCP) from Chum Salmon skin by using two wound models (incision and excision) in rats.

Results: Ninety-six animals were equally divided into the two wound models and then within each model animals were randomly divided into two groups: vehicle-treated group and 2 g kg(-1) MCP-treated group. Wound closure and tensile strength were calculated. Collagen deposition was assessed by Masson staining and hydroxyproline measurement. Angiogenesis was assessed by immunohistological methods. MCP-treated rats showed faster wound closure and improved tissue regeneration at the wound site, which was supported by histopathological parameters pertaining to wound healing. MCP treatment improved angiogenesis and helped form thicker and better organised collagen fibre deposition compared to vehicle-treated group.

Conclusion: The results show the efficacy of oral MCP treatment on wound healing in animals.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Angiogenesis Inducing Agents / administration & dosage
  • Angiogenesis Inducing Agents / therapeutic use*
  • Animals
  • Collagen / administration & dosage
  • Collagen / therapeutic use*
  • Dietary Supplements
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Fish Proteins / administration & dosage
  • Fish Proteins / therapeutic use
  • Hydroxyproline / metabolism
  • Immunohistochemistry
  • Male
  • Neovascularization, Physiologic*
  • Oncorhynchus keta / metabolism*
  • Peptide Fragments / administration & dosage
  • Peptide Fragments / therapeutic use*
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Regeneration
  • Skin / chemistry
  • Skin / injuries
  • Skin / metabolism*
  • Skin / pathology
  • Skin Physiological Phenomena
  • Tensile Strength
  • Time Factors
  • Wound Healing*


  • Angiogenesis Inducing Agents
  • Fish Proteins
  • Peptide Fragments
  • Collagen
  • Hydroxyproline