Side-specific expression of activated leukocyte adhesion molecule (ALCAM; CD166) in pathosusceptible regions of swine aortic valve endothelium

J Heart Valve Dis. 2011 Mar;20(2):165-7.


Aortic valve sclerosis (AVS), an early form of aortic valve disease, develops preferentially on the aortic side of valve leaflets, a predilection that is reflected in an heterogeneous side-specific gene expression profile. It has been ascertained that hypercholesterolemia is sufficient to initiate the endothelial expression of activated leukocyte adhesion molecule (ALCAM; CD166), restricted to the aortic side of the leaflet. Intercellular adhesion molecule-1 (ICAM-1) or vascular cell adhesion molecule-1 (VCAM-1)--both of which are more typically associated with early arterial inflammation--are not differentially expressed. ALCAM up-regulation by hypercholesterolemia suggests a side-specific spatial role in the recruitment of leukocytes to AVS sites.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Activated-Leukocyte Cell Adhesion Molecule / genetics
  • Activated-Leukocyte Cell Adhesion Molecule / metabolism*
  • Animals
  • Aortic Valve / immunology*
  • Aortic Valve / pathology
  • Endothelial Cells / immunology*
  • Endothelial Cells / pathology
  • Gene Expression Profiling
  • Heart Valve Diseases / genetics
  • Heart Valve Diseases / immunology*
  • Heart Valve Diseases / pathology
  • Hypercholesterolemia / complications*
  • Hypercholesterolemia / genetics
  • Hypercholesterolemia / immunology
  • Hypercholesterolemia / pathology
  • Immunohistochemistry
  • Inflammation Mediators / metabolism*
  • Intercellular Adhesion Molecule-1 / metabolism
  • Sclerosis
  • Swine
  • Up-Regulation
  • Vascular Cell Adhesion Molecule-1 / metabolism


  • Activated-Leukocyte Cell Adhesion Molecule
  • Inflammation Mediators
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1