Rho GTPase effector functions in tumor cell invasion and metastasis

Curr Drug Targets. 2011 Jul 1;12(8):1194-201. doi: 10.2174/138945011795906534.

Abstract

Rho GTPases (Ras homologous family) comprise the largest subfamily cluster of the Ras-homology superfamily. Rho GTPases exist in inactive GDP and active GTP forms. The active forms of the Rho family members bind with numerous effector proteins that are crucial for various biological processes. Accumulating evidence exemplifies the importance of Rho effector proteins in various steps of cancer progression. Here, we highlight the actions of various effectors of Rho members in cancer invasion and metastasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / physiology
  • Humans
  • Molecular Targeted Therapy
  • Neoplasm Metastasis / physiopathology*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / physiopathology*
  • rac1 GTP-Binding Protein / physiology
  • rho GTP-Binding Proteins / genetics
  • rho GTP-Binding Proteins / physiology*

Substances

  • Adaptor Proteins, Signal Transducing
  • RAC1 protein, human
  • CDC42EP1 protein, human
  • rac1 GTP-Binding Protein
  • rho GTP-Binding Proteins