Rab GTPases, membrane trafficking and diseases

Curr Drug Targets. 2011 Jul 1;12(8):1188-93. doi: 10.2174/138945011795906561.

Abstract

The Rab family of GTPases contains over 60 genes in the human genome and contributes to regulation of intracellular membrane trafficking along endocytic and exocytic pathways as well as specialized pathways in specific cell types. It has become increasingly clear that disruption of the intracellular membrane trafficking system at different stages can cause various diseases. In the past decade, altered expression levels and mutations of Rab GTPases have been associated with such diseases as cancer, Alzheimer's disease, and various genetic disorders. This review discusses the specific Rab GTPases and their involvement in the diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / physiopathology
  • Biological Transport / genetics
  • Biological Transport / physiology
  • Genetic Diseases, Inborn / physiopathology
  • Humans
  • Intracellular Membranes / physiology*
  • Molecular Targeted Therapy*
  • Mutation
  • Neoplasms / genetics
  • Neoplasms / physiopathology
  • Signal Transduction / physiology
  • rab GTP-Binding Proteins / genetics
  • rab GTP-Binding Proteins / physiology*

Substances

  • rab GTP-Binding Proteins