Absence of association between GSTM1 and GSTT1 polymorphisms and melanoma susceptibility: a meta-analysis

DNA Cell Biol. 2011 Oct;30(10):783-8. doi: 10.1089/dna.2010.1198. Epub 2011 May 12.


Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. The null genotypes GSTM1 and GSTT1 have been implicated in the development of carcinogenesis. We conducted a meta-analysis to examine the association of GSTM1 and GSTT1 homozygous deletion polymorphisms with melanoma risk. In total, 8 relevant studies were identified in searches of the PubMed and Embase databases: 8 investigated GSTM1 (1349 cases and 1560 controls) and 5 GSTT1 (977 cases and 1060 controls). Fixed- and random-effects models were used to assess the summary odds ratios (ORs). No significant association of the GSTM1 and GSTT1 polymorphisms or the GSTM1-GSTT1 interaction on the risk of melanoma was observed (for GSTM1: OR=1.09; 95% confidence interval, 0.94-1.27; and for GSTT1: OR=0.95; 95% confidence interval, 0.76-1.19). Similarly, no significant association was found in a subgroup analysis of hair color. These results indicate that the GSTM1 and GSTT1 polymorphisms may not be a risk factor for developing melanoma.

Publication types

  • Meta-Analysis

MeSH terms

  • Australia
  • Case-Control Studies
  • Chile
  • Databases, Bibliographic
  • Europe
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Glutathione Transferase / genetics*
  • Hair Color / genetics*
  • Homozygote
  • Humans
  • Melanoma / epidemiology
  • Melanoma / genetics*
  • Melanoma / pathology
  • Odds Ratio
  • Polymorphism, Genetic
  • Risk Factors
  • Skin / pathology*
  • Skin Neoplasms / epidemiology
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / pathology
  • United States


  • glutathione S-transferase T1
  • Glutathione Transferase
  • glutathione S-transferase M1