Non-small-cell lung cancer

Lancet. 2011 Nov 12;378(9804):1727-40. doi: 10.1016/S0140-6736(10)62101-0. Epub 2011 May 10.


In the decade since the last Lancet Seminar on lung cancer there have been advances in many aspects of the classification, diagnosis, and treatment of non-small-cell lung cancer (NSCLC). An international panel of experts has been brought together to focus on changes in the epidemiology and pathological classification of NSCLC, the role of CT screening and other techniques that could allow earlier diagnosis and more effective treatment of the disease, and the recently introduced seventh edition of the TNM classification and its relation to other prognostic factors such as biological markers. We also describe advances in treatment that have seen the introduction of a new generation of chemotherapy agents, a proven advantage to adjuvant chemotherapy after complete resection for specific stage groups, new techniques for the planning and administration of radiotherapy, and new surgical approaches to assess and reduce the risks of surgical treatment.

Publication types

  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / genetics
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Carcinoma, Non-Small-Cell Lung / pathology*
  • Carcinoma, Non-Small-Cell Lung / therapy*
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Early Diagnosis
  • ErbB Receptors / antagonists & inhibitors
  • Exhalation
  • Genetic Predisposition to Disease
  • Humans
  • Lung / diagnostic imaging
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / therapy*
  • Lymph Node Excision
  • Lymph Nodes / pathology
  • Mass Screening
  • Multimodal Imaging
  • Neoplasm Grading
  • Neoplasm Staging
  • Pneumonectomy
  • Positron-Emission Tomography
  • Prognosis
  • Radiotherapy, Image-Guided
  • Risk Assessment
  • Terminology as Topic
  • Thoracic Surgery, Video-Assisted
  • Tomography, X-Ray Computed
  • Volatile Organic Compounds / metabolism


  • Biomarkers, Tumor
  • Volatile Organic Compounds
  • ErbB Receptors