Estrogen receptor transrepresses brain inflammation

David Gosselin; Serge Rivest

doi:10.1016/j.cell.2011.04.018

Estrogen receptor transrepresses brain inflammation

Cell. 2011 May 13;145(4):495-7. doi: 10.1016/j.cell.2011.04.018.

Authors

David Gosselin¹, Serge Rivest

Affiliation

¹ Laboratory of Endocrinology and Genomics, CHUQ Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, 2705 Laurier Boulevard, Québec, G1V 4G2, Canada.

PMID: 21565607
DOI: 10.1016/j.cell.2011.04.018

Abstract

Estrogen receptors (ERs) have long been implicated in the etiology of multiple sclerosis, but no clear molecular mechanisms have linked ERs to the disease's pathology. Now Saijo et al. (2011) provide evidence that ERβ activates a transrepression pathway that suppresses inflammation and inhibits progression of pathology in a mouse model of multiple sclerosis.

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