Metformin Activates an Ataxia Telangiectasia Mutated (ATM)/Chk2-regulated DNA Damage-Like Response

Cell Cycle. 2011 May 1;10(9):1499-501. doi: 10.4161/cc.10.9.15423. Epub 2011 May 1.

Publication types

  • Letter

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins
  • Carcinoma, Squamous Cell / enzymology
  • Carcinoma, Squamous Cell / genetics
  • Carcinoma, Squamous Cell / pathology*
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Cell Line, Tumor
  • Checkpoint Kinase 2
  • DNA Damage / drug effects
  • DNA Damage / genetics
  • DNA-Binding Proteins / genetics*
  • DNA-Binding Proteins / metabolism
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / genetics
  • Diabetes Mellitus, Type 2 / pathology*
  • Enzyme Activation / drug effects
  • Enzyme Activation / genetics
  • Humans
  • Metformin / pharmacology*
  • Protein-Serine-Threonine Kinases / genetics*
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Serine-Threonine Kinases / physiology*
  • Tumor Suppressor Proteins / genetics*
  • Tumor Suppressor Proteins / metabolism

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Tumor Suppressor Proteins
  • Metformin
  • Checkpoint Kinase 2
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • CHEK2 protein, human
  • Protein-Serine-Threonine Kinases