Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report

Child Adolesc Psychiatry Ment Health. 2011 May 13;5(1):15. doi: 10.1186/1753-2000-5-15.


Anti-NMDA-Receptor encephalitis is a severe form of encephalitis that was recently identified in the context of acute neuropsychiatric presentation. Here, we describe the case of a 17-year-old girl referred for an acute mania with psychotic features and a clinical picture deteriorated to a catatonic state. Positive diagnosis of anti-NMDA-receptor encephalitis suggested specific treatment. She improved after plasma exchange and immunosuppressive therapy. Post-cognitive sequelae (memory impairment) disappeared within 2-year follow-up and intensive cognitive rehabilitation.