Cell communication networks in cancer invasion

Curr Opin Cell Biol. 2011 Oct;23(5):621-9. doi: 10.1016/j.ceb.2011.04.010. Epub 2011 May 11.


The invasion of cancer is a major clinical problem. It is now apparent that invasion is not a simply a cancer cell autonomous process but relies on a complex network of paracrine interactions. Furthermore, this network can change as cancer cells disseminate. Here we summarise the key components of the network and their mechanisms of communication. Finally, we discuss the difficulties and opportunities that this complex network of interactions presents during cancer therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Communication*
  • Extracellular Matrix / metabolism
  • Humans
  • Neoplasm Metastasis
  • Neoplasms / metabolism
  • Neoplasms / pathology*