Studies for the application of boron neutron capture therapy to the treatment of differentiated thyroid cancer

A Dagrosa; M Carpano; M Perona; L Thomasz; S Nievas; R Cabrini; G Juvenal; M Pisarev

doi:10.1016/j.apradiso.2011.02.030

Studies for the application of boron neutron capture therapy to the treatment of differentiated thyroid cancer

Appl Radiat Isot. 2011 Dec;69(12):1752-5. doi: 10.1016/j.apradiso.2011.02.030. Epub 2011 Mar 15.

Authors

A Dagrosa¹, M Carpano, M Perona, L Thomasz, S Nievas, R Cabrini, G Juvenal, M Pisarev

Affiliation

¹ Department of Radiobiology, National Atomic Energy Commission (CNEA), San Martin, Argentina. dagrosa@cnea.gov.ar

PMID: 21570311
DOI: 10.1016/j.apradiso.2011.02.030

Abstract

The aim of these studies was to evaluate the possibility of treating differentiated thyroid cancer by BNCT. These carcinomas are well controlled with surgery followed by therapy with (131)I; however, some patients do not respond to this treatment. BPA uptake was analyzed both in vitro and in nude mice implanted with cell lines of differentiated thyroid carcinoma. The boron intracellular concentration in the different cell lines and the biodistribution studies showed the selectivity of the BPA uptake by this kind of tumor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Boron Compounds / metabolism
Boron Neutron Capture Therapy*
Cell Differentiation
Cell Line, Tumor
Humans
Mice
Mice, Nude
Phenylalanine / analogs & derivatives
Phenylalanine / metabolism
Thyroid Neoplasms / pathology
Thyroid Neoplasms / radiotherapy*

Substances

Boron Compounds
Phenylalanine
4-boronophenylalanine