Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats

Klin Wochenschr. 1990 Jan 19;68(2):142-5. doi: 10.1007/BF01646863.


Treatment of normal adult rats with pyridoxine or a B-vitamin mixture resembling Neurobion led to an increase in serotonin content of various brain areas and to a decrease in the number of serotonin S2 receptors. The results indicate that the pyridoxal phosphate level in regions of the brain regulates the extent of decarboxylation of 5-hydroxytryptophan, the precursor of serotonin. The results also suggest a continuum from deficiency in pyridoxine to treatment of animals with a moderate excess of pyridoxine which is reflected in the synthesis and secretion into the synaptic cleft of the neurotransmitter serotonin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Afferent Pathways / drug effects
  • Animals
  • Brain / drug effects*
  • Nociceptors / drug effects*
  • Pyridoxine / pharmacology
  • Rats
  • Receptors, Serotonin / drug effects*
  • Serotonin / metabolism
  • Spinal Cord / drug effects
  • Synaptic Transmission / drug effects
  • Synaptosomes / drug effects
  • Vitamin B Complex / pharmacology*


  • Receptors, Serotonin
  • Vitamin B Complex
  • Serotonin
  • Pyridoxine