Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanism

Jan Kitajewski

doi:10.1016/j.devcel.2011.05.001

Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanism

Dev Cell. 2011 May 17;20(5):577-8. doi: 10.1016/j.devcel.2011.05.001.

Author

Jan Kitajewski¹

Affiliation

¹ Department of Ob/Gyn, Pathology, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA. jkk9@columbia.edu

Abstract

Guarani et al. (2011), reporting in Nature, identify a mechanism for fine-tuning endothelial Notch signaling by SIRT1-mediated deacetylation. This regulation is critical for vascular sprouting and raises intriguing questions about therapeutic targeting of SIRT1 in angiogenesis and the potential mechanisms that link vascular growth and energy homeostasis.

Publication types

Comment

Grants and funding

R01 HL062454/HL/NHLBI NIH HHS/United States