Reduced movement-related β desynchronisation in juvenile myoclonic epilepsy: a MEG study of task specific cortical modulation

Clin Neurophysiol. 2011 Nov;122(11):2128-38. doi: 10.1016/j.clinph.2011.04.017. Epub 2011 May 14.


Objective: We investigated differences in task induced responses in occipital and sensorimotor cortex between patients with juvenile myclonic epilepsy (JME) and healthy controls .

Methods: Twelve patients with JME and 12 age-matched non-epilepsy volunteers performed visual and motor tasks during MEG. We used synthetic aperture magnetometry to localise areas of task-related oscillatory modulations, performed time-frequency analyses on the locations of peak task related power changes and compared power and frequency modulation at these locations between patients and controls.

Results: Patients with JME had significantly reduced pre-movement beta event-related desynchronisation in the motor task compared to controls. No significant differences were seen in other motor-related responses, or visual oscillatory responses.

Conclusions: Altered beta event-related desynchronisation may represent network specific dysfunction in JME possibly through GABAergic dysfunction.

Significance: Characterising task specific cortical responses in epilepsy offers the potential to understand the patho-physiological basis of seizures and provide a window on disease and treatment effects.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Beta Rhythm / physiology*
  • Cerebral Cortex / physiopathology*
  • Cortical Synchronization / physiology*
  • Female
  • Humans
  • Magnetoencephalography / methods*
  • Male
  • Myoclonic Epilepsy, Juvenile / diagnosis*
  • Myoclonic Epilepsy, Juvenile / physiopathology
  • Psychomotor Performance / physiology*
  • Young Adult