RcsB is required for inducible acid resistance in Escherichia coli and acts at gadE-dependent and -independent promoters

J Bacteriol. 2011 Jul;193(14):3653-6. doi: 10.1128/JB.05040-11. Epub 2011 May 13.


RcsB interacts with GadE to mediate acid resistance in stationary-phase Escherichia coli K-12. We show here that RcsB is also required for inducible acid resistance in exponential phase and that it acts on promoters that are not GadE regulated. It is also required for acid resistance in E. coli O157:H7.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids / metabolism*
  • Escherichia coli K12 / genetics
  • Escherichia coli K12 / growth & development
  • Escherichia coli K12 / metabolism*
  • Escherichia coli O157 / genetics
  • Escherichia coli O157 / growth & development
  • Escherichia coli O157 / metabolism*
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism*
  • Gene Expression Regulation, Bacterial*
  • Promoter Regions, Genetic*
  • Protein Binding
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*


  • Acids
  • Escherichia coli Proteins
  • GadE protein, E coli
  • RcsB protein, E coli
  • Transcription Factors