Meta-analysis of Genome-Wide Association Studies Identifies Common Variants Associated With Blood Pressure Variation in East Asians

Nat Genet. 2011 Jun;43(6):531-8. doi: 10.1038/ng.834. Epub 2011 May 15.

Abstract

We conducted a meta-analysis of genome-wide association studies of systolic (SBP) and diastolic (DBP) blood pressure in 19,608 subjects of east Asian ancestry from the AGEN-BP consortium followed up with de novo genotyping (n = 10,518) and further replication (n = 20,247) in east Asian samples. We identified genome-wide significant (P < 5 × 10(-8)) associations with SBP or DBP, which included variants at four new loci (ST7L-CAPZA1, FIGN-GRB14, ENPEP and NPR3) and a newly discovered variant near TBX3. Among the five newly discovered variants, we obtained significant replication in the independent samples for all of these loci except NPR3. We also confirmed seven loci previously identified in populations of European descent. Moreover, at 12q24.13 near ALDH2, we observed strong association signals (P = 7.9 × 10(-31) and P = 1.3 × 10(-35) for SBP and DBP, respectively) with ethnic specificity. These findings provide new insights into blood pressure regulation and potential targets for intervention.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian Continental Ancestry Group / genetics*
  • Blood Pressure / genetics*
  • Diastole / genetics
  • European Continental Ancestry Group / genetics
  • Far East
  • Gene Frequency
  • Genome-Wide Association Study*
  • Humans
  • Polymorphism, Single Nucleotide
  • Systole / genetics