Computerized double-tracer subtraction scanning with gallium-67 citrate in inflammatory diseases

J Nucl Med. 1978 Dec;19(12):1297-300.


A gallium-67/technetium-99m subtraction technique was used with a variable weighting factor. That is, each image was separately set to 100%. Varying amounts of the Tc-99m images were subtracted from those of Ga-67. A total of 95 patients who had radiogallium scanning for suspected inflammatory disease were studied by the subtraction technique. Thirty of these patients had abnormal Tc-99m pyrophosphate bone scans, while 20 had abnormal radiogallium abdominal foci; 45 had defects in liver, spleen, or kidney images. The subtraction technique with variable weighting was highly successful in enhancing hot-spot visibility, and in providing information as to the anatomic location of the defect.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abscess / diagnostic imaging
  • Adult
  • Arthritis, Infectious / diagnostic imaging
  • Citrates
  • Computers
  • Diphosphates
  • Female
  • Gallium Radioisotopes*
  • Humans
  • Inflammation / diagnostic imaging*
  • Kidney Diseases / diagnostic imaging
  • Liver Abscess / diagnostic imaging
  • Male
  • Middle Aged
  • Osteomyelitis / diagnostic imaging
  • Radionuclide Imaging / methods*
  • Splenic Diseases / diagnostic imaging
  • Technetium


  • Citrates
  • Diphosphates
  • Gallium Radioisotopes
  • Technetium