A human ADP/ATP translocase gene has seven pseudogenes and localizes to chromosome X

Somat Cell Mol Genet. 1990 Mar;16(2):143-9. doi: 10.1007/BF01233044.


There are at least three transcriptionally active human ADP/ATP translocase genes. We have isolated seven ADP/ATP translocase pseudogenes from recombinant human genomic libraries. Each pseudogene sequence had more than 85% identity with the sequence of the human ADP/ATP translocase cDNA derived from fibroblast mRNA, but each had mutations that precluded synthesis of a functional protein. Using an intron probe derived from a partial clone of the human fibroblast ADP/ATP translocase gene, we localized the gene to chromosome Xq13----Xq25-26. The gene encoding the skeletal muscle translocase has previously been shown to be on chromosome 4. Therefore, the human ADP/ATP translocase genes are members of a multigene family that includes pseudogenes and has been dispersed to at least two chromosomes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Southern
  • Cell Line
  • Chromosome Mapping
  • Chromosomes, Human, Pair 10 / analysis
  • Chromosomes, Human, Pair 10 / ultrastructure*
  • DNA / analysis
  • DNA / genetics
  • Fibroblasts / metabolism
  • Gene Expression
  • Humans
  • Hybrid Cells / cytology
  • Hybrid Cells / enzymology
  • Introns
  • Mitochondrial ADP, ATP Translocases / genetics*
  • Molecular Sequence Data
  • Nucleotidyltransferases / genetics*
  • Pseudogenes*
  • Restriction Mapping
  • Transcription, Genetic


  • DNA
  • Mitochondrial ADP, ATP Translocases
  • Nucleotidyltransferases