[Systemic enzymotherapy in the combined treatment of infectious endocarditis in drug addicts]

Klin Med (Mosk). 2011;89(2):53-5.
[Article in Russian]


The aim of this study was to elucidate effects of systemic enzymotherapy on the clinical course of infectious endocarditis and the frequency of thromboembolic complications in drug addicts compared with controls. Another objective was to develop an optimal regime of enzymotherapy depending on the severity of the disease. Inclusion of wobenzyme in the combined treatment of infectious endocarditis permitted to accelerate the achievement of clinical improvement, normalize blood rheologic characteristics, reduce severity of intoxication and systemic inflammation, decrease the frequency of septic thromboembolia of the pulmonary artery.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Combined Modality Therapy
  • Drug Combinations
  • Endocarditis, Bacterial / complications*
  • Endocarditis, Bacterial / drug therapy*
  • Enzyme Therapy / adverse effects
  • Enzyme Therapy / methods*
  • Female
  • Humans
  • Hydrolases / adverse effects
  • Hydrolases / therapeutic use*
  • Male
  • Rutin / adverse effects
  • Rutin / therapeutic use*
  • Substance-Related Disorders / complications*
  • Thromboembolism / chemically induced
  • Thromboembolism / diagnosis
  • Young Adult


  • Drug Combinations
  • Rutin
  • Wobenzym
  • Hydrolases