D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes

Brain Res. 1990 Feb 26;510(1):158-60. doi: 10.1016/0006-8993(90)90745-w.

Abstract

In the Xenopus oocyte preparation, D-cycloserine (DCS) had the profile of a partial agonist at the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine. Glycine and D-serine were agonists at this site. The actions of DCS were competitively antagonized by HA-966, a known glycine antagonist.

MeSH terms

  • Animals
  • Cycloserine / pharmacology*
  • Glycine / pharmacology
  • Glycine / physiology*
  • Oocytes / metabolism
  • Oocytes / physiology*
  • Pyrrolidinones / pharmacology
  • RNA, Messenger
  • Rats
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter / drug effects*
  • Receptors, Neurotransmitter / physiology
  • Xenopus laevis

Substances

  • Pyrrolidinones
  • RNA, Messenger
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Neurotransmitter
  • Cycloserine
  • 1-hydroxy-3-amino-2-pyrrolidone
  • Glycine