Persistent primary hypogonadism associated with anabolic steroid abuse

Fertil Steril. 2011 Jul;96(1):e7-8. doi: 10.1016/j.fertnstert.2011.04.029. Epub 2011 May 14.


Objective: To report a case of primary gonadal failure due to the chronic abuse of anabolic steroids used for bodybuilding.

Design: Case report.

Setting: Department of Diabetes and Endocrinology, Morriston Hospital, Swansea, Wales, United Kingdom.

Patient(s): A 40-year-old man.

Intervention(s): None.

Main outcome measure(s): Clinical symptoms, levels of serum T, FSH, and LH.

Result(s): Primary gonadal failure resulting from anabolic steroid use.

Conclusion(s): We describe a case of initially secondary gonadal failure resulting from anabolic steroid use with subsequent primary gonadal failure and infertility. This case adds to the current literature and illustrates that the side effects of anabolic steroids can be prolonged and irreversible.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anabolic Agents / adverse effects*
  • Anabolic Agents / blood
  • Growth Hormone / adverse effects
  • Growth Hormone / blood
  • Humans
  • Hypogonadism / blood
  • Hypogonadism / chemically induced*
  • Hypogonadism / diagnosis*
  • Male
  • Nandrolone / adverse effects
  • Nandrolone / blood
  • Steroids / adverse effects
  • Steroids / blood
  • Substance-Related Disorders / blood
  • Substance-Related Disorders / diagnosis*
  • Testosterone / adverse effects
  • Testosterone / blood


  • Anabolic Agents
  • Steroids
  • Testosterone
  • Nandrolone
  • Growth Hormone