The anticancer effect of antineoplaston A-10 on human breast cancer serially transplanted to athymic mice

Nihon Gan Chiryo Gakkai Shi. 1990 Jan 20;25(1):1-5.

Abstract

We report the effects of Antineoplaston A-10 Injection on the growth curve of human breast cancer (R-27) serially transplanted to athymic mice. The intraperitoneal administration of 1/4 LD-50 (50 mg/mouse) of Antineoplaston A-10 Injection every day and 1/2 LD-50 (100 mg/mouse) every other day for 35 days was found to significantly inhibit the growth curve and also the 3H-TdR uptake was inhibited by 73.7% in those given 1/4 LD-50 and by 77.1% in those given 1/2 LD-50. The tumor histology in both groups showed necrosis but no lymphocyte infiltration.

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Benzeneacetamides*
  • Breast Neoplasms / drug therapy*
  • Carcinoma, Intraductal, Noninfiltrating / drug therapy*
  • Female
  • Humans
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Piperidines / therapeutic use*
  • Piperidones*
  • Transplantation, Heterologous

Substances

  • Antineoplastic Agents
  • Benzeneacetamides
  • Piperidines
  • Piperidones
  • antineoplaston A10