Okadaic acid: a new probe for the study of cellular regulation

Trends Biochem Sci. 1990 Mar;15(3):98-102. doi: 10.1016/0968-0004(90)90192-e.

Abstract

The tumour promoter okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A. Here we review recent studies which demonstrate that this toxin is extremely useful for identifying biological processes that are controlled through the reversible phosphorylation of proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carcinogens
  • Cell Extracts
  • Cells / drug effects
  • Diarrhea / etiology
  • Ethers, Cyclic* / metabolism
  • Ethers, Cyclic* / pharmacology
  • Ethers, Cyclic* / toxicity
  • Humans
  • Okadaic Acid
  • Oxazoles / pharmacology
  • Oxazoles / toxicity
  • Phosphoprotein Phosphatases / analysis
  • Phosphoprotein Phosphatases / antagonists & inhibitors
  • Phosphorylation
  • Shellfish Poisoning

Substances

  • Carcinogens
  • Cell Extracts
  • Ethers, Cyclic
  • Oxazoles
  • Okadaic Acid
  • calyculin A
  • Phosphoprotein Phosphatases