Placebo-controlled trial of the effects of guar gum and metformin on fasting blood glucose and serum lipids in obese, type 2 diabetic patients

Diabet Med. Mar-Apr 1990;7(3):242-5. doi: 10.1111/j.1464-5491.1990.tb01378.x.

Abstract

Nineteen obese patients with Type 2 diabetes mellitus were treated for periods of 3 months with placebo, guar gum (5 g three times daily) and metformin (500 mg three times daily) in a randomized double-blind, double-placebo, cross-over study. Both active agents decreased fasting blood glucose from 11.4 +/- 3.7 mmol l-1 (mean +/- SD) to 8.6 +/- 2.8 mmol l-1 on metformin (p less than 0.001) and to 9.5 +/- 3.9 mmol l-1 on guar gum (p less than 0.01). Metformin significantly reduced the very low density lipoprotein (VLDL) cholesterol concentration from 0.62 (+0.73, -0.34) mmol l-1 (geometric mean (+SD, -SD)) to 0.43 (+0.58, -0.25) mmol l-1, (p less than 0.02), but unless hyperlipidaemia was present there were no changes in other serum lipid or lipoprotein levels. In patients with serum cholesterol greater than 6.5 mmol l-1 decreases in serum triglycerides from 3.29 (+3.27, -1.64) to 2.46 (+2.55, -1.25) mmol l-1 (p less than 0.02) occurred with metformin. In these patients guar gum produced a reduction in serum cholesterol (from 7.70 +/- 0.90 to 6.41 +/- 1.11 mmol l-1, p less than 0.01) due to an effect on low density lipoproteins. These differential effects may be important in planning therapy when hyperlipidaemia accompanies Type 2 diabetes.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoproteins B / blood
  • Blood Glucose / metabolism*
  • Cholesterol / blood
  • Cholesterol, LDL / blood
  • Clinical Trials as Topic
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / drug therapy
  • Diabetes Mellitus / therapy*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / therapy*
  • Diet, Diabetic
  • Dietary Fiber / therapeutic use*
  • Fasting
  • Female
  • Galactans / therapeutic use*
  • Humans
  • Lipids / blood*
  • Male
  • Mannans / therapeutic use*
  • Metformin / therapeutic use*
  • Middle Aged
  • Obesity*
  • Placebos
  • Plant Gums
  • Triglycerides / blood

Substances

  • Apolipoproteins B
  • Blood Glucose
  • Cholesterol, LDL
  • Dietary Fiber
  • Galactans
  • Lipids
  • Mannans
  • Placebos
  • Plant Gums
  • Triglycerides
  • Metformin
  • Cholesterol
  • guar gum