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, 59 (3), 246-8

Massive Retinal Gliosis: An Unusual Case With Immunohistochemical Study

Case Reports

Massive Retinal Gliosis: An Unusual Case With Immunohistochemical Study

Sanjay D Deshmukh et al. Indian J Ophthalmol.


Massive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells. Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein. We encountered a case of a 45-year-old female with loss of vision in the left eye. She had a history of trauma to that eye two years ago. Enucleation was carried out, because malignancy was suspected due to retinal calcification. On the basis of light microscopy and immunohistochemistry (IHC) performed on the enucleated eye, it was diagnosed as massive retinal gliosis.


Figure 1
Figure 1
Computed tomogram-scan showing deformed left eyeball with homogenous haze and areas of calcification
Figure 2
Figure 2
The retina is replaced by spindle-shaped glial cells arranged in interlacing bundles and whorls (H and E, ×100). Individual cells are elongated, with abundant eosinophilic fibrillary cytoplasm (Inset) (H and E, ×400)
Figure 3
Figure 3
On an immunohistochemical study the spindle-shaped cells show intense immunoreactivity for glial fibrillary acidic protein (IHC)

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