Abstract
Topical application of 4-aminopyridine (4-AP) onto hippocampal slices produced spontaneous repetitive large hyperpolarizing potentials in CA1 neurons. This effect of 4-AP was blocked by a new GABAB receptor antagonist, 2-hydroxy-saclofen. 2-Hydroxy-saclofen also blocked slow IPSPs evoked by stimulation of stratum radiatum. It is suggested that 4-AP-evoked slow hyperpolarizing potentials are in fact slow IPSPs evoked by activation of a selective subset of interneurons which do not produce fast IPSPs.
MeSH terms
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4-Aminopyridine / pharmacology*
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Action Potentials / drug effects
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Animals
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Baclofen / analogs & derivatives
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Baclofen / pharmacology
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GABA-A Receptor Antagonists
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Hippocampus / physiology*
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In Vitro Techniques
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Interneurons / drug effects
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Interneurons / physiology*
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Neural Inhibition / drug effects*
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Rats
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Receptors, GABA-A / physiology
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gamma-Aminobutyric Acid / pharmacology
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gamma-Aminobutyric Acid / physiology*
Substances
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GABA-A Receptor Antagonists
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Receptors, GABA-A
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gamma-Aminobutyric Acid
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4-Aminopyridine
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Baclofen
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2-hydroxysaclofen