A subset of local interneurons generate slow inhibitory postsynaptic potentials in hippocampal neurons

Brain Res. 1990 Mar 12;511(1):163-4. doi: 10.1016/0006-8993(90)90236-5.

Abstract

Topical application of 4-aminopyridine (4-AP) onto hippocampal slices produced spontaneous repetitive large hyperpolarizing potentials in CA1 neurons. This effect of 4-AP was blocked by a new GABAB receptor antagonist, 2-hydroxy-saclofen. 2-Hydroxy-saclofen also blocked slow IPSPs evoked by stimulation of stratum radiatum. It is suggested that 4-AP-evoked slow hyperpolarizing potentials are in fact slow IPSPs evoked by activation of a selective subset of interneurons which do not produce fast IPSPs.

MeSH terms

  • 4-Aminopyridine / pharmacology*
  • Action Potentials / drug effects
  • Animals
  • Baclofen / analogs & derivatives
  • Baclofen / pharmacology
  • GABA-A Receptor Antagonists
  • Hippocampus / physiology*
  • In Vitro Techniques
  • Interneurons / drug effects
  • Interneurons / physiology*
  • Neural Inhibition / drug effects*
  • Rats
  • Receptors, GABA-A / physiology
  • gamma-Aminobutyric Acid / pharmacology
  • gamma-Aminobutyric Acid / physiology*

Substances

  • GABA-A Receptor Antagonists
  • Receptors, GABA-A
  • gamma-Aminobutyric Acid
  • 4-Aminopyridine
  • Baclofen
  • 2-hydroxysaclofen