Bronchiolitis obliterans. A new clinical-pathologic complication of irradiation pneumonitis

Chest. 1990 May;97(5):1243-4. doi: 10.1378/chest.97.5.1243.


A patient underwent chest irradiation for small-cell carcinoma of the left lung. Several weeks following cessation of irradiation, the patient developed hypoxemia and reticulonodular densities within the radiation port. Open lung biopsy yielded a pathologic diagnosis consistent with irradiation pneumonitis along with a previously unreported association, bronchiolitis obliterans. Bronchiolitis obliterans should be included in the pathologic description of irradiation pneumonitis.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Bronchiolitis Obliterans / etiology*
  • Carcinoma, Small Cell / radiotherapy
  • Humans
  • Lung / radiation effects
  • Lung Neoplasms / radiotherapy
  • Male
  • Middle Aged
  • Pneumonia / etiology*
  • Radiotherapy / adverse effects*