Natural products containing a diazo group

Nat Prod Rep. 2011 Aug;28(8):1426-44. doi: 10.1039/c1np00031d. Epub 2011 May 18.


Although diazo compounds are probably best known for their involvement as versatile intermediates in modern synthetic organic chemistry, a small number of such compounds also occur naturally. Many of the early examples, such as azaserine, originally isolated in the 1950s, have antitumour properties and consist of modified α-amino acids. More recently, other more complex diazo compounds have been isolated from natural sources, and these include diazobenzoquinones, diazonaphthoquinones, such as the SF2415 and A80915 antibiotics, and the diazofluorene-based kinamycins and lomaiviticins. This report will cover the isolation, biosynthesis, biological activity and synthesis of natural products containing a diazo group.

Publication types

  • Review

MeSH terms

  • Azo Compounds / chemistry*
  • Azo Compounds / isolation & purification
  • Azo Compounds / pharmacology
  • Biological Products / chemistry*
  • Biological Products / isolation & purification
  • Biological Products / pharmacology
  • Molecular Structure


  • Azo Compounds
  • Biological Products