Acute HIV-1 Infection

N Engl J Med. 2011 May 19;364(20):1943-54. doi: 10.1056/NEJMra1011874.


In 2009, the United Nations Estimated that 33.2 Million People worldwide were living with human immunodeficiency virus type 1 (HIV-1) infection and that 2.6 million people had been newly infected. The need for effective HIV-1 prevention has never been greater. In this review, we address recent critical advances in our understanding of HIV-1 transmission and acute HIV-1 infection. Fourth-generation HIV-1 testing, now available worldwide,, will allow the diagnosis of infection in many patients and may lead to new treatments and opportunities for prevention.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Disease
  • Adaptive Immunity
  • Disease Progression
  • HIV Infections / diagnosis
  • HIV Infections / immunology
  • HIV Infections / prevention & control
  • HIV Infections / transmission*
  • HIV-1* / immunology
  • Humans