The role of cytokines IL-6 and IL-8 in the pathogenesis of spontaneous abortions

J Matern Fetal Neonatal Med. 2011 Oct;24(10):1283-5. doi: 10.3109/14767058.2011.575482. Epub 2011 May 19.


Objective: The aim of this study was to investigate the role of interleukin-6 and interleukin-8 in the spontaneous abortion of the first and second trimester of pregnancy and the possibility of IL-6 and IL-8 being used as markers for the pregnancy outcome.

Method: The patients were divided into three groups: group 1, women at the time of first trimester miscarriage (n = 35); group 2, women at the time of second trimester miscarriage (n = 35); group 3 included the women without previous history of abortions submitted to hysterectomy (n = 10). Plasma levels of interleukin-6 and interleukin-8 were measured by bioassays method (ELISA). Mann-Whitney U test and Kruskal-Wallis test were used to assess differences between two or more groups of patients, respectively. Post hoc analysis was performed using Mann-Whitney U test with Bonferroni's correction.

Results: Interleukin 6 levels in women who had a second trimester abortion were statistically higher compared to those who had a first trimester abortion. Interleukin-8 levels in patients with second trimester abortion were also statistically higher compared to the control group. No significant differences between women with first trimester abortions and those without previous history of abortions were found.

Conclusions: Our data suggest that IL-6 and IL-8 might be crucial factors which take part in the defensive reaction of maternal organization during the 2nd trimester of pregnancy.

MeSH terms

  • Abortion, Spontaneous / blood*
  • Abortion, Spontaneous / immunology
  • Adolescent
  • Adult
  • Biomarkers / blood
  • Female
  • Humans
  • Interleukin-6 / blood*
  • Interleukin-8 / blood*
  • Middle Aged
  • Predictive Value of Tests
  • Pregnancy
  • Pregnancy Outcome*
  • Pregnancy Trimester, Second
  • Prospective Studies
  • Young Adult


  • Biomarkers
  • CXCL8 protein, human
  • IL6 protein, human
  • Interleukin-6
  • Interleukin-8