Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2011 Aug;217(2):447-51.
doi: 10.1016/j.atherosclerosis.2011.04.015. Epub 2011 Apr 27.

Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts

Delilah Zabaneh  1 , Meena Kumari, Manj Sandhu, Nick Wareham, Nick Wainwright, Theodore Papamarkou, Jemma Hopewell, Robert Clarke, KaWah Li, Jutta Palmen, Philippa J Talmud, Florian Kronenberg, Claudia Lamina, Monika Summerer, Bernhard Paulweber, Jackie Price, Gerry Fowkes, Marlene Stewart, Fotios Drenos, Sonia Shah, Tina Shah, Juan-Pablo Casas, Mika Kivimaki, John Whittaker, Aroon D Hingorani, Steve E Humphries
Affiliations
Meta-Analysis

Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts

Delilah Zabaneh et al. Atherosclerosis. 2011 Aug.

Abstract

Background: Both genome-wide association studies and candidate gene studies have reported that the major determinant of plasma levels of the Lipoprotein (a) [Lp(a)] reside within the LPA locus on chromosome 6. We have used data from the HumanCVD BeadChip to explore the contribution of other candidate genes determining Lp(a) levels.

Methods: 48,032 single nucleotide polymorphisms (SNPs) from the Illumina HumanCVD BeadChip were genotyped in 5059 participants of the Whitehall II study (WHII) of randomly ascertained healthy men and women. SNPs showing association with Lp(a) levels of p<10(-4) outside the LPA locus were selected for replication in a total of an additional 9463 participants of five European based studies (EAS, EPIC-Norfolk, NPHSII, PROCARDIS, and SAPHIR).

Results: In Whitehall II, apart from the LPA locus (where p values for several SNPs were <10(-30)) there was significant association at four loci GALNT2, FABP1, PPARGC1A and TNFRSFF11A. However, a meta-analysis of the six studies did not confirm any of these findings.

Conclusion: Results from this meta analysis of 14,522 participants revealed no candidate genes from the HumanCVD BeadChip outside the LPA locus to have an effect on Lp(a) levels. Further studies with genome-wide and denser SNP coverage are required to confirm or refute this finding.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Forest plots for the five studies and seven SNPs for rs10455872 (LPA) and rs17069904 (TNFRSFF11A).
Figure 1
Figure 1
Forest plots for the five studies and seven SNPs for rs10455872 (LPA) and rs17069904 (TNFRSFF11A).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Dieplinger H, Utermann G. The seventh myth of lipoprotein(a): where and how is it assembled? Current Opinion in Lipidology. 1999;10:275–283. - PubMed
    1. Utermann G, Menzel HJ, Kraft HG, Duba HC, Kemmler HG, Seitz C. Lp(A) Glycoprotein Phenotypes - Inheritance and Relation to Lp(A)-Lipoprotein Concentrations in Plasma. Journal of Clinical Investigation. 1987;80:458–465. - PMC - PubMed
    1. Kraft HG, Kochl S, Menzel HJ, Sandholzer C, Ubermann G. The Apolipoprotein(A) Gene - A Transcribed Hypervariable Iocus Controlling Plasma Lipoprotein(A) Concentration. Circulation. 1992;86:337. - PubMed
    1. Erqou S, Kaptoge S, Perry PL, et al. Lipoprotein(a) Concentration and the Risk of Coronary Heart Disease, Stroke, and Nonvascular Mortality. Jama-Journal of the American Medical Association. 2009;302:412–423. - PMC - PubMed
    1. Nordestgaard GB, Chapman MJ, Ray K, et al. Lipoprotein(a) as a cardiovascular risk factor: current status. European Heart Journal. 2010 doi: 10.1093/eurheartj/ehq3. epub ahead of print. - DOI - PMC - PubMed

Publication types