DNA origami: a quantum leap for self-assembly of complex structures

Chem Soc Rev. 2011 Dec;40(12):5636-46. doi: 10.1039/c1cs15057j. Epub 2011 May 19.


The spatially controlled positioning of functional materials by self-assembly is one of the fundamental visions of nanotechnology. Major steps towards this goal have been achieved using DNA as a programmable building block. This tutorial review will focus on one of the most promising methods: DNA origami. The basic design principles, organization of a variety of functional materials and recent implementation of DNA robotics are discussed together with future challenges and opportunities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • DNA / chemistry*
  • Humans
  • Nanotechnology / methods*
  • Nucleic Acid Conformation*
  • Robotics


  • DNA