Paralytic ileus requiring hospitalization secondary to high-dose antipsychotic polypharmacy and benztropine

Gen Hosp Psychiatry. 2011 Mar-Apr;33(2):200.e5-7. doi: 10.1016/j.genhosppsych.2010.10.005. Epub 2010 Dec 3.


Ileus can result from the combined activity of antipsychotic and anticholinergic medications. Despite frequent use, case reports in the literature are sparse. We present a patient who developed a paralytic ileus requiring extended hospitalization. Providers should minimize antipsychotic and concurrent anticholinergic medications, consider prophylactic bowel regimens and monitor for constipation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antipsychotic Agents / adverse effects*
  • Benztropine / adverse effects*
  • Drug Therapy, Combination / adverse effects*
  • Female
  • Gastrointestinal Tract / diagnostic imaging
  • Gastrointestinal Tract / physiopathology
  • Hospitalization*
  • Humans
  • Intestinal Pseudo-Obstruction / chemically induced*
  • Muscarinic Antagonists / adverse effects*
  • Polypharmacy*
  • Radiography


  • Antipsychotic Agents
  • Muscarinic Antagonists
  • Benztropine