Immunohistology of Epstein-Barr virus-associated antigens in B cell disorders from immunocompromised individuals

Transplantation. 1990 May;49(5):944-53. doi: 10.1097/00007890-199005000-00022.


Proliferating B cell lesions developing in a series of immunosuppressed organ transplant recipients and patients with X-linked lymphoproliferative syndrome were examined for Epstein-Barr virus and cellular gene expression using immunocytochemistry and immunoblotting techniques. Results indicate that all the lesions examined from the patients in this series expressed Epstein-Barr virus gene products that were consistent with a latent, nonproductive type of infection. No lytic cycle antigens associated with productive viral infection were detected. This pattern is similar to the viral gene expression in normal B cells immortalized by Epstein-Barr virus in vitro. The demonstration in this study of Epstein-Barr virus viral gene expression in posttransplant and X-linked proliferative syndrome B cell disorders provides important new evidence for the primary role of Epstein-Barr virus in the development of these lesions. This is in contrast to the subsidiary role that the Epstein-Barr virus has in the etiology of Burkitt's lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, Differentiation, B-Lymphocyte / analysis
  • Antigens, Viral / genetics
  • Antigens, Viral / immunology*
  • B-Lymphocytes / microbiology*
  • Blotting, Western
  • Cell Adhesion Molecules / analysis
  • Gene Expression
  • Herpesvirus 4, Human / genetics
  • Herpesvirus 4, Human / immunology*
  • Humans
  • Immunosuppression Therapy / adverse effects
  • Leukemia, Lymphocytic, Chronic, B-Cell / microbiology
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Lymphoproliferative Disorders / genetics
  • Lymphoproliferative Disorders / microbiology*
  • Lymphoproliferative Disorders / pathology


  • Antibodies, Monoclonal
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, Viral
  • Cell Adhesion Molecules