Complex regional pain syndrome

Foot Ankle Clin. 2011 Jun;16(2):351-66. doi: 10.1016/j.fcl.2011.03.001.

Abstract

Complex regional pain syndrome (CRPS) is a challenging pain condition for doctors and patients, with a natural history characterized by chronicity and relapses that can result in significant disability. CRPS is difficult to diagnose and treat, and requires close follow-up to ensure that progress is being made. Early diagnosis and treatment are required to prevent a long-standing or permanent disability. Clinical features such as spontaneous pain, edema, hyperalgesia, temperature or sudomotor changes, motor function abnormality, and autonomic changes are the hallmark of this disease. The treatment of CRPS remains controversial, and includes medications, physical therapy, regional anesthesia, and neuromodulation.

Publication types

  • Review

MeSH terms

  • Amines / therapeutic use
  • Analgesics / therapeutic use
  • Analgesics, Opioid / therapeutic use
  • Anesthesia, Conduction
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antidepressive Agents / therapeutic use
  • Autonomic Nerve Block
  • Causalgia / diagnosis
  • Causalgia / therapy
  • Complex Regional Pain Syndromes / classification
  • Complex Regional Pain Syndromes / diagnosis*
  • Complex Regional Pain Syndromes / genetics
  • Complex Regional Pain Syndromes / physiopathology
  • Complex Regional Pain Syndromes / therapy*
  • Cyclohexanecarboxylic Acids / therapeutic use
  • Diphosphonates / therapeutic use
  • Electromyography
  • Free Radical Scavengers / therapeutic use
  • Gabapentin
  • Glucocorticoids / therapeutic use
  • Humans
  • Osteoporosis / diagnosis
  • Physical Therapy Modalities
  • Skin / innervation
  • Thermography
  • Treatment Outcome
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Amines
  • Analgesics
  • Analgesics, Opioid
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antidepressive Agents
  • Cyclohexanecarboxylic Acids
  • Diphosphonates
  • Free Radical Scavengers
  • Glucocorticoids
  • gamma-Aminobutyric Acid
  • Gabapentin